Macrolide antibiotics in diffuse panbronchiolitis and in cystic fibrosis

Macrolide antibiotics in diffuse panbronchiolitis and in cystic fibrosis.

I share the interest shown by EVERARD et al. [1] in the use of macrolide antibiotics in cystic fibrosis (CF). Some patients with chronic Pseudomonas colonization do appear to improve when given prolonged courses of azithromycin, and the possibility that this is due to an anti-inflammatory rather than an antibacterial effect is supported by the findings of MOLINARI et al. [2] that subinhibitory ...

Macrolide antibiotics and cystic fibrosis.

Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis.

Diffuse panbronchiolitis (DPB) is a pulmonary disease characterized by chronic inflammation of the bronchioles and chronic infiltration of inflammatory cells in the lungs. DPB has several features in common with cystic fibrosis (CF). Clinical trials in patients with DPB or CF suggest a potential role for maintenance (long-term and low-dose) macrolide therapy in the treatment of these chronic pu...

Diffuse panbronchiolitis and cystic fibrosis: East meets West.

Antibiotics in Cystic Fibrosis.

IN cystic fibrosis the main problem is the susceptibility of the children to respiratory infection. The clinical course of the untreated case is one of repeated respiratory infections followed by persistent pulmonary sepsis, and later death. Severe attacks may occur in the first weeks or months of life, or less commonly, years may pass with no, or minimal symptoms referable to the chest. Upper ...